Abses Hepar dengan Reaksi Leukemoid dan Kultur Abses No Growth: Sebuah Laporan Kasus Langka dengan Tantangan Diagnostik dan Terapi

Akbar Shiddiq, Helmi Purba, Asrizal Asrizal, Marlina Tasril, Andikha Putra, Riski Dimas, Najwa Firstsa Ananda, Hesti Andika Putri

Abstract

Liver abscess is an infection of the hepatic parenchyma caused by bacterial or parasitic pathogens. Based on its etiology, it is classified into pyogenic liver abscess and amebic liver abscess. Leukemoid reaction and Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) are rare conditions associated with this disease. We report a case of a 28-year-old male who presented with right upper abdominal pain and was diagnosed with amebic liver abscess following comprehensive evaluation. The condition was further complicated by a leukemoid reaction, which raised suspicion of an underlying hematological disorder, as well as hypoalbuminemia and hyponatremia, strongly suggestive of SIADH. The coexistence of these conditions in the context of liver abscess presents significant challenges in both diagnosis and management. Precise diagnosis and integrated management are essential to achieving favorable outcomes.

Keywords

amebic liver abscess; hypoalbuminemia; leukemoid reaction; liver abcess; SIADH

References

Alwi I, Salim S, editor. Abses hepar. Dalam: Penatalaksanaan di Bidang Ilmu Penyakit Dalam: Panduan Praktik Klinis. Edisi ke-3. Jakarta: Interna Publishing; 2017. hlm. 217–23.

Nasrallah J, Akhoundi M, Haouchine D, Marteau A, Mantelet S, Wind P, et al. Updates on the worldwide burden of amoebiasis: A case series and literature review. J Infect Public Health. 2022 Oct 1;15(10):1134–41.

Mahendra M, Prasetyo AD. Abses hepar : Sebuah laporan kasus. Collaborative Medical Journal (CMJ). 2021 Nov 11;4(1):1–7.

Hakim Z, Kurniawan J. Abses hepar. Dalam: Setiati S, Alwi I, Sudoyo AW, Simadibrata M, Nasution SA, Syam AF, editor. Buku Ilmu Penyakit Dalam. Edisi VII. Jakarta: Interna Publishing; 2024. hlm. 2367–73.

Salim R, Sabir M, Diana V, Wahyuni RD. Diagnosis dan manajemen abses hepar. Jurnal Medical Profession (MedPro). 2023; 5.

Holzheimer RG, Mannick JA, editors. Pyogenic and amebic liver abscess . In: Surgical treatment: Evidence-Based and Problem-Oriented. Munich; 2018.

Gupta K, Rn P, Kumar R, Anand U, Ja P, Ml D, et al. Amebic liver abscess: Clinico- radiological findings and interventional management. Vol. 14, World Journal of Radiology Contents Monthly. 2022

Kapil M. Leukemoid Reaction-An Update. Clinical Pathology & ResearchJournal. 2019;3(1).

Alvarado Hernández RA, Mayorga Lira G de J. Amebic liver abscess of rare localization. Cir Gen. 2022;44(2):77–82.

Abbas Z, Ahmad A, Khan AH. Syndrome of inappropriate secretion of antidiuretichormone (SIADH) in amoebic liver abscess. J Infect. 1997;34(1):79–81.

Kumar R, Patel R, Priyadarshi RN, Narayan R, Maji T, Anand U, et al. Amebic liver abscess: An update. Vol. 16, World Journal of Hepatology. Baishideng Publishing Group Inc; 2024. p. 316–30

Kannathasan S, Murugananthan A, Kumanan T, De Silva NR, Rajeshkannan N, Haque R, et al. Epidemiology and factors associated with amoebic liver abscess in northern Sri Lanka. BMC Public Health. 2018;18(1):1–8.

Trillos-Almanza MC, Restrepo Gutierrez JC. How to manage: Liver abscess. Frontline Gastroenterol. 2021;12(3):225–31.

Tee K, Dang J. The suspect - SIADH. Aust Fam Physician. 2017;46(9):677–80.

Rafat C, Flamant M, Gaudry S, Vidal-Petiot E, Ricard JD, Dreyfuss D. Hyponatremia in the intensive care unit: How to avoid a Zugzwang situation? Ann Intensive Care. 2015;5(1):1–27.

Jha AK, Jha P, Chaudhary M, Purkayastha S, Jha SK, Ranjan R, et al. Evaluation of factors associated with complications in amoebic liver abscess in a predominantly toddy- drinking population: A retrospective study of 198 cases. JGH Open. 2019;3(6):474–9.

Putra PA, Suardamana K. Diagnostic approach of liver abscess. Int J Adv Med.

DOI: https://doi.org/10.26891/JIK.v19i2.2025.205-209

Refbacks

  • There are currently no refbacks.