Kombinasi Tetrahidrokurkumin dan Cyanidine-3-O-β-glucoside sebagai Terapi Fitokimia Asma Anak melalui Penghambatan IL-4Rα-STAT6 dan Sitokin Proinflamasi

Afid Brilliana Putra, Muhammad Ilham Dhiya Rakasiwi, Ihya Fakhrurizal Amin

Abstract

Asthma is chronic inflammatory disease experienced mostly by children with prevalence of 4.5% in Indonesia. Asthma puts burden on sufferers because of the long duration of treatment. However, prolonged inhaled corticosteroids use in certain doses can cause side effects. Tetrahydrocurcumin (THC) is metabolite of curcumin and has higher bioavailability than its precursor molecules. THC has been shown to significantly reduce leukocyte infiltration, as well as inhibit inflammation through IL-4Rα pathway and decrease GATA3 expression. The same effect is obtained from Cyanidine-3-O-β-glucoside (Cy-3-g). The anti-inflammatory effect of those combination can be used as alternative phytochemical therapy to treat asthma in children.

Keywords

asthma, cyanidine-3-O-β-glucoside, tetrahydrocurcumin, Th2 response

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References

Soriano JB, Abajobir AA, Abate KH, Abera SF, Agrawal A, Ahmed MB, et al. Global, regional, and national deaths, prevalence, disability adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med. 2017; 5:691–706.

Asher I, Pearce N. Global burden of asthma among children. Int J Tuberc Lung Dis. 2014; 18: 1269–78.

Pusdatin Kemenkes RI. Infodatin Asma. Kementerian Kesehatan Republik Indonesia. Jakarta

Akinbami LJ, Simon AE, Rossen LM. Changing Trends in Asthma Prevalence Among Children. Pediatrics. 2016; 137(1): 1–7

Bowen H, Kelly A, Lee T, Lavender P. Control of cytokine gene transcription in Th1 and Th2 cells. Clin Exp Allergy. 2008; 38: 1422–31

Lambrecht BN, Hammad H. Biology of lung dendritic cells at the origin of asthma. Immunity . 2009; 31: 412–24

Schuijs MJ, Willart MA, Hammad H, Lambrecht B N. Cytokine targets in airway inflammation. Curr Opin Pharmacol.2013; 13: 351–61

Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Lordan JL. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol. 2000; 105: 193–204

Chen BL, Chen YQ, Ma BH, Yu SF, Li LY, Zeng QX, et al. Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Rα-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. Clin Exp Allergy. 2018 Sep 12;48(11):1494–508.

Galván CA, Guarderas JC. Practical Considerations for Dysphonia Caused by Inhaled Corticosteroids. MCP. 2012 Sep;87(9):901–4.

Kelly HW, Sternberg AL, Lescher R, Fuhlbrigge AL, Williams P, Zeiger RS, et al. Effect of Inhaled Glucocorticoids in Childhood on Adult Height. NEJM. 2012 ;367(10):904–12.

Holgate ST. Trials and tribulations in identifying new biologic treatments for asthma. Trends Immunol. 2012;33(5):238–46.

Ma B, Wu Y, Chen B, Yao Y, Wang Y, Bai H, et al. Cyanidin-3-O-β-glucoside attenuates allergic airway inflammation by modulating the IL-4Rα-STAT6 signaling pathway in a murine asthma model. Int Immunopharmacol. 2019 ;69:1–10.

Ho IC, Tai TS, Pai SY. GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nature Rev Immunol. 2009 ;9(2):125–35.

Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M. Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proceedings of the National Academy of Sciences. 2011; 108(16):6615–20.

Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnology Advances. 2014; 32(6):1053–64.

Asai, A.; Miyazawa, T. Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. Life Sci. 2000; 67: 2785–93

Hong, J.; Lambert, J.D.; Lee, S.H.; Sinko, P.J.; Yang, C.S. Involvement of multidrug resistance-associated proteins in regulating cellular levels of (−)-epigallocatechin-3-gallate and its methyl metabolites. Biochem Biophys Res Commun. 2003; 310: 222–7.

Tsuda T, Horio F, Osawa T. Absorption and metabolism of cyanidin 3-o-β-d-glucoside in rats. FEBS Lett. 1999; 449(2–3): 179–82.

Park SJ, Shin WH, Seo JW, Kim EJ. Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model. Food Chem Toxicol. 2007; 45(8): 1459–67.

Tomkinson A, Duez C, Lahn M, Gelfand EW. Adoptive transfer of T cells induces airway hyperresponsiveness independently of airway eosinophilia but in a signal transducer and activator of transcription 6-dependent manner. J Allergy Clin Immunol. 2002; 109(5): 810–6.

Pyo MY, Yoon SJ, Yu Y, Park S, Jin M. Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells. Bioscience, Biotechnology, and Biochemistry. 2014; 78(6):1037–43.

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of Curcumin: Problems and Promises. Molecular Pharmaceutics. 2007; 4(6):807–18.

Aggarwal BB, Deb L, Prasad S. Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules. 2015;20(1):185-205.

Manarin G, Anderson D, Silva JME, et al. Curcuma longa L. ameliorates asthma control in children and adolescents: A randomized, double-blind, controlled trial. J Ethnopharmacol. 2019;238:111882.

Nejatbakhsh F, Karegar-Borzi H, Amin G, et al. Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial. J Ethnopharmacol. 2017;196:186-192.

Zhang L, Zengin G, Mahomoodally MF, et al. Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn. Plants (Basel). 2022;11(5):600.

DOI: https://doi.org/10.26891/JIK.v16i1.2022.9-15

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