Efektivitas HE4 sebagai Metode Skrining Terbaru untuk Diagnosis Dini Kanker Ovarium

Amru Sofian, Hendra Perkasa, Ega Rahman Evsya, Riyan M Darundryo


The tumor marker CA125 is one of the currently used biomarkers to detect ovarian cancer. The tumor
marker CA125 also elevated in other diseases. Human epididymis protein 4 is used as a new biomarker for
early detection of ovarian cancer. Human epididymis protein 4 is increased in almost all patients with
ovarian cancer and increased only slightly at a fraction of other diseases. Human epididymis protein 4 has
a better effectiveness in detecting ovarian cancer when combined with CA125. From the study of literature
found that the combination of HE4 and CA125 had a specificity of 96.3% and 92.9% sensitivity.


Ovarian cancer, effectiveness, CA125, HE4

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