Efektivitas HE4 sebagai Metode Skrining Terbaru untuk Diagnosis Dini Kanker Ovarium

Abstract

The tumor marker CA125 is one of the currently used biomarkers to detect ovarian cancer. The tumor
marker CA125 also elevated in other diseases. Human epididymis protein 4 is used as a new biomarker for
early detection of ovarian cancer. Human epididymis protein 4 is increased in almost all patients with
ovarian cancer and increased only slightly at a fraction of other diseases. Human epididymis protein 4 has
a better effectiveness in detecting ovarian cancer when combined with CA125. From the study of literature
found that the combination of HE4 and CA125 had a specificity of 96.3% and 92.9% sensitivity.