Immunosenescence : Penuaan Pada Sel Makrofag

Fajri Marindra Siregar

Abstract

Immune function will decrease with age. The weakening of immune system is known as immunosenescence. Macrophages that play a major role in carrying out innate and adaptive immune functions have potential to undergo aging (macrophaging). Some potential mechanisms that can affect the aging of macrophages include telomere shortening, oxidative damage and impaired DNA repair processes. The impact of macrophaging can be a decrease number of macrophages in bone marrow, changing cytokine secretion, decreasing class II MHC expression, changing macrophages polarization, decreasing ability of phagocytosis, and decreasing ability of wound repair and tissue regeneration.

Keywords

aging, immunosenescence, macrophages

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References

Linehan E, Fitzgerald DC. Ageing and the immune system: focus on macrophages. Eur J Microbiol Immunol. 2015;5(1):14–24.

Mahbub S, Brubaker AL, Kovacs EJ. Aging of the innate immune system: an update. Curr Immunol Rev. 2011;7(1):104–15.

Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM. Aging of the innate immune system. Curr Opin Immunol. 2010;22(4):507–13.

Isobe K-I, Nishio N, Hasegawa T. Immunological aspects of age-related diseases. World J Biol Chem. 2017;8(2):129–37.

Lloberas J, Celada A. Effect of aging on macrophage function. Exp Gerontol. 2002;37(12):1325–31.

Medina KL. Overview of the immune system. Handb Clin Neurol. 2016;133:61–76.

Weiskopf D, Weinberger B, Grubeck-Loebenstein B. The aging of the immune system. Transpl Int Off J Eur Soc Organ Transplant. 2009;22(11):1041–50.

Dace DS, Apte RS. Effect of senescence on macrophage polarization and angiogenesis. Rejuvenation Res. 2008;11(1):177–85.

Sebastián C, Espia M, Serra M, Celada A, Lloberas J. MacrophAging: a cellular and molecular review. Immunobiology. 2005;210(2–4):121–6.

Herrero C, Marqués L, Lloberas J, Celada A. IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice. J Clin Invest. 2001;107(4):485–93.

Sun L-Q, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, et al. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev. 2004;18(9):1035–46.

Blasco MA. Immunosenescence phenotypes in the telomerase knockout mouse. Springer Semin Immunopathol. 2002;24(1):75–85.

Weng N. Interplay between telomere length and telomerase in human leukocyte differentiation and aging. J Leukoc Biol. 2001;70(6):861–7.

Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol. 2004;75(2):342–9.

Chelvarajan RL, Collins SM, Van Willigen JM, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol. 2005;77(4):503–12.

Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F. Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol. 2010;11:30.

Herrero C, Sebastián C, Marqués L, Comalada M, Xaus J, Valledor AF, et al. Immunosenescence of macrophages: reduced MHC class II gene expression. Exp Gerontol. 2002;37(2–3):389–94.

Mahbub S, Deburghgraeve CR, Kovacs EJ. Advanced age impairs macrophage polarization. J Interferon Cytokine Res Off J Int Soc Interferon Cytokine Res. 2012;32(1):18–26.

Ogawa T, Kitagawa M, Hirokawa K. Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages. Mech Ageing Dev. 2000;117(1–3):57–68.

De La Fuente M. Changes in the macrophage function with aging. Comp Biochem Physiol A. 1985;81(4):935–8.

Aprahamian T, Takemura Y, Goukassian D, Walsh K. Ageing is associated with diminished apoptotic cell clearance in vivo. Clin Exp Immunol. 2008;152(3):448–55.

Swift ME, Burns AL, Gray KL, DiPietro LA. Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol. 2001;117(5):1027–35.

Ruckh JM, Zhao J-W, Shadrach JL, van Wijngaarden P, Rao TN, Wagers AJ, et al. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell. 2012;10(1):96–103.

DOI: https://doi.org/10.26891/JIK.v13i1.2019.14-22

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