Immunosenescence : Penuaan Pada Sel Makrofag

Fajri Marindra Siregar

Abstract

Immune function will decrease with age. The weakening of immune system is known as immunosenescence.
Macrophages that play a major role in carrying out innate and adaptive immune functions have potential to undergo
aging (macrophaging). Some potential mechanisms that can affect the aging of macrophages include telomere
shortening, oxidative damage and impaired DNA repair processes. The impact of macrophaging can be a decrease
number of macrophages in bone marrow, changing cytokine secretion, decreasing class II MHC expression, changing
macrophages polarization, decreasing ability of phagocytosis, and decreasing ability of wound repair and tissue
regeneration.

Keywords

aging, immunosenescence, macrophages

Full Text:

PDF

Refbacks

  • There are currently no refbacks.