Pengaruh Injeksi Platelet Rich Plasma Terhadap Proses Penyembuhan Luka Fase Remodeling Berdasarkan Early Wound Healing Score (EHS) pada Kasus Sistokel

Betrisya Hanifah, Jojor Sihotang

Abstract

Pelvic organ prolapse (POP) is a common condition in postpartum women, with cystocele being the most common type. Anterior colporrhaphy is a commonly used treatment, but it has a relatively high recurrence rate. Platelet-rich plasma (PRP) is known to have the potential to enhance wound healing through tissue regeneration. This study aims to analyze the effect of PRP injection on remodeling phase wound healing based on the Early Wound Healing Score (EHS) assessment in cystocele cases. The study design used was a retrospective cohort, with data taken from medical records using a consecutive sampling method on 40 women who underwent anterior colporrhaphy. A total of 20 patients who received PRP injection were included in the case group, while 20 other patients who did not receive PRP injection were the control group. The EHS score was assessed on the 14th and 28th days postoperatively. Data analysis was performed using the independent t-test on day 14 and the Mann-Whitney test on day 28. The results showed a significant increase in the mean EHS score in the case group compared to the control group, both on day 14 and day 28. In conclusion, PRP injection during cystocele surgery has been proven effective in accelerating wound healing in the remodeling phase and has the potential to be an additional therapy to reduce the risk of recurrence.

Keywords

Pelvic Organ Prolapse; Early Wound Healing Score; Cystocele; wound healing; remodeling phase; Platelet Rich Plasma

References

Hamahata Y, Akagi K, Maeda T, Nemoto K, Koike J. Management of Pelvic Organ Prolapse (POP) and Rectal Prolapse. J Anus, Rectum Colon. 2022 Apr 27;6(2):2020–007.

Enikeev ME, Enikeev DV, Korolev DO, Snurnitsyna OV, Lobanov MV, Nikitin AN, et al. Repair of cystocele and apical genital prolapse using 6-strap mesh implant. Urol J. 2020 Aug 16;87(3):130–6.

Makajeva J, Watters C, Safioleas P. Cystocele. In Treasure Island (FL); 2024.

Roziana, Fathanah NN. Recurrent pelvic organ prolapse after surgery. Jurnal Kedokteran Syiah Kuala. 2022; doi:10.24815/jks.v0i0.26654.

Meutia AP, Santoso BI, Djusad S. Role of Platelet-Rich Plasma Application on Mesh-Tissue Integration. Indones J Obstet Gynecol. 2023;11(2):124–7.

Sheean AJ, Anz AW, Bradley JP. Platelet-Rich Plasma: Fundamentals and Clinical Applications. 2021;37(9):2732–4.

Kurniawati EM, Rahmawati NA, Hardianto G, Paraton H, Hadi THS. Role of platelet-rich plasma in pelvic floor disorders: A systematic review. Int J Reprod Biomed. 2023;21(12):957–74.

Conde-Montero E, de la Cueva Dobao P, Martínez González JM. Platelet-rich plasma for the treatment of chronic wounds: evidence to date. Chronic Wound Care Manag Res. 2017;Volume 4:107–20.

Marini L, Sahrmann P, Rojas MA, Cavalcanti C, Pompa G, Papi P, Pilloni A. Early wound healing score (EHS): An intra- and inter-examiner reliability study. Dent J (Basel). 2019;7(3):86.

Karina K, Rosliana I, Rosadi I, Sobariah S, Christoffel LM, Novariani R, et al. Phase I/II clinical trial of autologous activated platelet-Rich Plasma (aaPRP) in the treatment of severe coronavirus disease 2019 (COVID-19) patients. Int J Inflam. 2021;2021(March 2020).

Mariani E, Pulsatelli L. Platelet concentrates in musculoskeletal medicine. Int J Mol Sci. 2020;21(4):9–12.

Marini L, Rojas MA, Sahrmann P, Aghazada R, Pilloni A. Early Wound Healing Score: A system to evaluate the early healing of periodontal soft tissue wounds. J Periodontal Implant Sci. 2018;48(5):274–83.

Xu P, Wu Y, Zhou L, Yang Z, Zhang X, Hu X, et al. Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization. Burn Trauma. 2021;8:1–14.

Sanoulis V, Nikolettos N, Vlahos N. The use of Platelet-Rich Plasma in the Gynaecological Clinical Setting. A review. Hjog. 2019;18(3):55–65.

Hua X, Zeng Y, Zhang R, Wang H, Diao J, Zhang P. Using platelet-rich plasma for the treatment of symptomatic cervical ectopy. Int J Gynecol Obstet [Internet]. 2012;119(1):26–9.

Odlozilova S, Paral J, Sirovy M, Zajak J, Fibir A. Platelet-Rich Plasma : Characteristics and Current Review of its Use in Surgery. 2024;96(5):59–67.

Seleem WM, Hanafy AS. The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer. Clin Endosc [Internet]. 2021 Nov 30;54(6):864–71.

Long DW, Johnson NR, Jeffries EM, Hara H, Wang Y. Controlled delivery of platelet-derived proteins enhances porcine wound healing. J Control Release [Internet]. 2017 May;253:73–81.

Patel H, Pundkar A, Shrivastava S, Chandanwale R, Jaiswal AM. A Comprehensive Review on Platelet-Rich Plasma Activation: A Key Player in Accelerating Skin Wound Healing. Cureus [Internet]. 2023 Nov 17;

Tehranian A, Esfehani-Mehr B, Pirjani R, Rezaei N, Sadat Heidary S, Sepidarkish M. Application of Autologous Platelet-Rich Plasma (PRP) on Wound Healing After Caesarean Section in High-Risk Patients. Iran Red Crescent Med J [Internet]. 2016 May 17;18(7). Available from: https://archive.ircmj.com/article/18/7/16821-pdf.pdf

Etulain J. Platelets in wound healing and regenerative medicine. Platelets [Internet]. 2018 Aug 18;29(6):556–68.

Cho EB, Park GS, Park SS, Jang YJ, Kim KH, Kim KJ, et al. Effect of platelet‐rich plasma on proliferation and migration in human dermal fibroblasts. J Cosmet Dermatol [Internet]. 2019 Aug 2;18(4):1105–12.

Elsaid A, El‐Said M, Emile S, Youssef M, Khafagy W, Elshobaky A. Randomized Controlled Trial on Autologous Platelet‐Rich Plasma Versus Saline Dressing in Treatment of Non‐healing Diabetic Foot Ulcers. World J Surg [Internet]. 2020 Apr 6;44(4):1294–301.

Dwi KD, Mardiyan KE, Hardianto G. The effect of platelet-rich plasma (PRP) injection on wound healing and sphincter ani muscle tone in post-repair of grade III-IV perineal tear patients. J Med Pharm Chem Res. 2025;7(8):1655–65.

Pavlovic V, Ciric M, Jovanovic V, Stojanovic P. Platelet Rich Plasma: a short overview of certain bioactive components. Open Med [Internet]. 2016 Jan 1;11(1):242–7.

Mohamadi S, Norooznezhad AH, Mostafaei S, Nikbakht M, Nassiri S, Safar H, et al. A randomized controlled trial of effectiveness of platelet-rich plasma gel and regular dressing on wound healing time in pilonidal sinus surgery: Role of different affecting factors. Biomed J [Internet]. 2019 Dec;42(6):403–10.

Willison N, Behnia-Willison F, Aryan P, Padhani ZA, Mirzaei Damabi N, Nguyen T, Yi J, Dutta R, Abbott D. Application of platelet-rich plasma in gynaecologic disorders: A scoping review. J Clin Med. 2025;14(16):5832

Moustakli E, Potiris A, Zikopoulos A, Zachariou A, Topis S, Panagopoulos P, Domali E, Drakakis P, Stavros S. Platelet-rich plasma (PRP) in reproductive medicine: A critical review of PRP therapy in low-reserve and premature ovarian insufficiency. Biomedicines. 2025;13(5):1257.

Streit-Ciećkiewicz D, Kołodyńska A, Futyma-Gąbka K, Grzybowska ME, Gołacki J, Futyma K. Platelet-rich plasma in gynecology—discovering the undiscovered: A review. Int J Environ Res Public Health. 2022;19(9):5284.

DOI: https://doi.org/10.26891/JIK.v20i1.2026.71-78

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