Perbandingan Mikroorganisme Pada Kultur Urin Pre-Operasi Dan Kultur Batu Pasca Operasi Pada Pasien Batu Saluran Kemih
Abstract
Urinary tract infection (UTI) and urinary tract calculi (UTC) still causes significant health problem and present as a dominant case in urology. Urine culture is a standard examination prior to UTC surgery which provide information on microorganism and its sensitivity to antibiotics. Despite of appropriate preoperative antibiotic therapy, we still found post operative infections among those patients. This study aims to determine if there any difference between urine and calculi culture in patients underwent UTC surgery. This is a comparative observational study in patients underwent urinary stone removal procedures from April 2022 to August 2022. Urinary culture attained 5-7 days prior to procedure and crushed calculi culture directly after procedure. The comparison between two examinations was performed. Total of 50 cases consisting of 33 (66%) males and 17 (34%) females was included. Patient with positive urine culture and calculi culture was 15 (30%) and 14 (28%) respectively. Only 3 (6%) patients positive for both, and only one patient with same pathogen. In 11 (22%) patients, we found positive calculi culture with previously sterile urine culture. Most common pathogen in urine culture was Escherichia coli, and Klebsiella pneumoniae found mostly in calculi culture. This study showed 21% accuracy, 66,67% specificity, 20% positive prediction value, 68,57% negative prediction value and 54% diagnostic accuracy. Low positive prediction value and diagnostic accuracy for microorganism of preoperative urine cultured was shown in this study. As a consequences, calculi culture is required as a routine examination during stone removal procedures.
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Miano R, Germani S, Vespasiani G. Stones and Urinary Tract Infections. Urology International Journal. 2012;7(9):32–36.
Purnomo BB. Dasar-dasar Urologi Edisi ke-3. Infeksi Urogenitalia. Jakarta: Sagung Seto; 2011. p.43-66
Noegroho BS, Daryanto B, Kadar DD, Soebadi DM, Hamiseno DM, Myh E, et al. Panduan Penatalaksanaan Klinis Batu Saluran Kemih. Ikatan Ahli Urologi Indonesia (IAUI). 2018;10(2):10-46.
Songra MC, Damor M, Namdev RK, Patbamaniya NK, Nawalakhe P, Jain R. A Study on Positive Stone Culture and Its Association With Rate of Sepsis After Urological Procedures. Intertional Surgeon Journal. 2015;1(2):239–46.
Kore AT, Singh G, Pawar SG. Bacteriological Profile of Urine in Patients with Urinary Calculi. Indian Journal Research. 2013;2(8):600-13.
Indrawan T, Hardjowijoto S, Soebadi DM, Juniastuti, Budiono. Correlation of Routine Urine Culture, Stone Culture, and Post Operative SIRS. International Journal of Urology. 2014;5(1):5-7.
Lorenzi ED, Boeri L, Gallioli A, Fontana M, Zanetti SP. Feasibilty and Relevance of Urine Culture During Stone Fragmentation in Patients Undergoing Percutaneus Nephrolithotomy and Retrograde Intrarenal Surgery. World Journal of Urology. 2020;5(1): 3-4.
Abhimanyu G, Nachiket V, Govind S, Shivam P, Deepak M, Prafulla K. A Comparison of Pre-Operative Urine Culture with Intra-Operative Stone Culture. African Journal of Urology. 2020;1(1):1-5.
Smith LA. Urinary Tract. National Institute of Diabetes and Digestive and Kidney Diseases Journal. 2020;5(3):2
Broeren AC, Bahceci S, Vader HL, Arents LA. Screening for Urinary Tract Infection with the Sysmex UF-1000i Urine Flow Cytometer. Journal Community of Medicine. 2011;9(3):1025–29.
Davis NF, Flood HD. The Pathogenesis of Urinary Tract Infections. Intech Journal. 2011;3(1):56-80.
Andersen BM. Prevention and Control of Infections in Hospital. Microbes, Transmission Routes and Survival Outside The Body. Switzerland: Spirenger; 2019. p.23-28
Engel LS. Multidrug-Resistant Gram-Negative Bacteria. Risk Factors and Treatments on Urinary Tract Infections. Clifton Park(NY): Thomson Delmar Learning; 2009. p. 34-55
Koser CU, Ellington MK, Carthwright EJ, Gillespie SH, Brown NM, Farrington M, et al. Routine Use of Microbial Whole Genome Sequencing in Diagnostic and Public Health Microbiology. PLOS Pathology Journal. 2012;8(1):24-28.
Collignon P. Resistant Escherichia coli (We Are What We Eat). Society of America Journal. 2009;15(7): 80-92.
Lydyard P. Case Studies in Infectious Disease. Journal Global Infectious Disease.2010;3(5):8.
Brooks GF, Carroll KC, Butel JS, Morse SA. Medical Microbiology 24th ED. New York: McGraw Hill Professional, 2010. p. 35-100.
Springter N. Epidemiology Urinary Tract Infection by Nature Reviews Molecular Cell Biology. 2015;13(5): 269–284.
Djide, MN. Dasar - Dasar Mikrobiologi. Makassar: Universitas Hasanuddin;2008. p. 10-35.
Partin A, Peters C, Kavousso L, Dmochowski R, Wein. Physiopathology and Etiology of Stone Formation in The Kidney and The Urinary Stones. Campbell-Walsh Urology 12th ED. USA: Elsevier; 2020. p. 3230-45
Alberto T. Urinary Calculi and Infection. World Journal of Urology. 2014;4(11):50-99.
Türk C, Neisius A, Petrik A, Seitz C, Skolarikos A, Tepeler A, et al. Guidelines on Urolithiasis. Europian Association of Urology. 2018;16(5): 2-20.
Heidenreich A. Modern Approach of Diagnosis and Management of Acute Flank Pain. Europe Urology Journal. 2009;4(1):351.
Worster A. The Accuracy of Noncontrast Helical Computed Tomography Versus Intravenous Pyelography in The Diagnosis of Suspected Acute Urolithiasis. Emerging Medicine Journal. 2012;4(7):259-80.
Charton M, Vallancien G, Veillon B, Brisset JM. Urinary Tract Infection for Percutaneous Surgery for Renal Calculi. Journal of Urology. 2009;6(3):135-45.
Prax M, Lee CY, Bannerman TL, Kloos WE, Euzeby JP, Fontana C, et al. UK Standarts for Microbiology Investigations. Standards Unit Microbiology Services, Public Health England Journal. 2019;11(1):39-49
Prihatini AH. Rapid Identification of Microorganism by Vitek-2. Airlangga University Press. 2007;3(7):1-5
Forbe BA, Sahm DF, Weissfeld AS. Bailey & Scott’s Diagnostic Microbiology. American Society for Microbiology Journal. 2007;8(10):199-201.
Paonessa EJ, Gnessin E, Bhojani N, Williams JC, Lingeman JE. Preoperative Bladder Urine Culture as a Predictor of Intraoperaitve Stone Culture Results: Clinical Implication and Relationship to Stone Composition. Journal Urology. 2016;3(09):3-4.
Tavichakorntrakool R, Prasongwattana V, Saisud P, Sribenjalux P, Pimratana C, Bovornpadungkitti S, et al. Extensive Characterizations of Bacteria Isolated from Catherterized Urine and Stone Matrices in Patients with Nephrolithiasis. Oxford University Press. 2012;29(03):4127-28.
Novianingsih A. Pola Sensitivitas Bakteri Terhadap Antibiotik pada Pasien Infeksi Saluran Kemih di RSUD Prof. Dr. W.Z Johannes Kupang Tahun 2018. Kupang. Politeknik Kesehatan Kemenkes Kupang. 2019.
Hidayat, Febriani U, Anggotomo W, Kurnia MA. Perbandingan Pola Sensitivitas Bakteri Terhadap Antibiotik Antara Ruang ICU dan Non ICU di Rumah Sakit Umum Daerah Dr. H. Abdul Moelek Provinsi Lampung Periode Januari-Maret Tahun 2019. Jurnal Medika Malahayati. 2020;1(01):58-59.
Oliphant CM. Pharmacoterapy Principle and Practices 14th ED. Antimicrobial Regiment Selection. New York: McGrow Hill Education; 2016. p. 1033-47
Mahendro HB. Pola Peta Kuman dan Sensitivitas Antibiotik pada Pasien di Intensive Care Unit (ICU) Rumah Sakit H. Adam Malik Medan januari-Desember 2018. Medan. Universitas Sumatera Utara. 2019.
Prayitno L, Siahaan S, Handayani RS. Analisis Efektivitas Biaya antara Penggunaan Meropenem dengan dan Tanpa Hasil Uji Sensitivitas Antibiotik pada Pasien Gagal Ginjal Kronik di Rumah Sakit. Buletin Penelitian Kesehatan. 2019;2(06):127-128.
Syahputra RR, Agustina D, Wahyudi SS. Pola Kepekaan Bakteri terhadap Antibiotik pada Pasien Infeksi Saluran Kemih di RSD Dr. Soebandi Jember. Journal of Agromedicine and Medical Scienses. 2018;4(03):175.
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