Antihyperglycemic and Antioxidant Properties of Jatropha curcas and Jatropha gossypifolia (Linn) Extracts

Albert Manggading Hutapea, Qori Fadillah

Abstract

The World Health Organization recommends the use of traditional medicines, including herbs, to maintain public health and prevent and treat diseases, especially chronic diseases, degenerative diseases, and cancer. Traditional medicine has relatively fewer side effects than modern pharmaceutical medicine. There have been many studies that explore secondary metabolites in plants. Among them, several plant species have been found to have antidiabetic properties. One of these plants is Jatropha curcas (Linn). Scientifically, it is known to exhibit antihyperglycemic and antioxidant activity. Phytochemical screening shows that the leaves of this plant species contain alkaloids, steroids, triterpenoids, flavonoids, and tannins, which are potentially antihyperglycemic, antioxidant, anti-cancer, and anti-inflammatory agents.

Keywords

Jatropha curcas (Linn), antihyperglycemic, antioxidant

Full Text:

PDF

References

Ghozali MSA. Uji in-vitro ekstrak daun jarak merah (Jatropha gossypiifolia L.) sebagai Inhibitor αAmilase (disertasi). Fakultas Matematika dan Ilmu Pengetahuan Alam: Universitas Jember; 2020.

Prawitasari DS. Diabetes melitus dan antioksidan. Keluwih: Jurnal Kesehatan Dan Kedokteran. 2019; 1(1): 48-52.

Baroroh HN, Rachmani EPN. Ketoksikan akut dari ekstrak etanolik daun jarak pagar (Jatropa curcas) pada mencit jantan galur balb/C. Jurnal Natur Indonesia.2013; 15(1): 52-56.

Nugroho AE. Hewan percobaan diabetes mellitus: patologi dan mekanisme aksi diabetogenik. Biodiversitas. 2006; 7(4): 378-382.

Nursahfitri, N., Amalia, R., Fadillah, Q. Uji efektivitas antibakteri ekstrak daun jarak pagar (Jatropha curcas Linn) terhadap bakteri Staphyloccocus aureus. Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat. 2020;5(4).

Warsinah, Baroroh H, Sunarto. Terapi inflamasi non infeksi berbasis herbal daun jarak pagar dengan pendekatan biomolekuler. Dalam Prosiding Seminar Nasional Sumber Daya Pedesaan dan Kearifan Lokal Berkelanjutan VII Purwokerto. 2017. p. 655-64.

Pingkan A, Yamlean PVY, Bodhi W. Uji efektivitas ekstrak etanol daun jarak pagar (Jatropha curcas l.) sebagai antihiperglikemia terhadap tikus putih jantan (rattus norvegicus). Pharmacon.2020; 9(4): 518-524.

Setyaningsih D, Pandji C, Perwatasari DD. Kajian aktivitas antioksidan dan antimikroba fraksi dan ekstrak dari daun dan ranting jarak pagar (Jatropha curcas l.) serta 126 pemanfaatannya pada produk personal hygiene. Agritech. 2014; 34(2): 126-137.

Farag M, Al-Rehaily A, Ahmad MS, Mothana RA. Detection of hypoglycemic and antidiabetic fraction in ethanol extract of Jatropha curcas aerial parts. Pharmacology & Pharmacy. 2014;5: 663-9.

Aladodo RA, Balogun EA, Sunmonu TO, Nurain IO. Combinatorial effects of aqueous root extract of Jatropha curcas and J. gossypiifolia in alloxan-induced diabetic rats. Iranian Journal of Toxicology.2017; 11(1): 11-7.

Ali FF., El-Baz FK, El-Rahman AAA, Aly HF, Mohamed AA, Saad SA. Attenuation of some metabolic deterioration induced by diabetes mellitus using different Jatropha curcas extracts. Int J Pharm Sci Rev Res. 2015; 30(2): 164-71.

Aladodo RA, Balogun EA. Effects of aqueous root extract of Jatropha curcas on hyperglycaemic and haematological indices in alloxan-induced diabetic rats. Fountain Journal of Natural and Applied Sciences. 2013; 2(1).

Augustina MA, Ogonga TA, Nwadiuto AC. A comparative study of the antioxidant and proteolytic activities of methanol extracts of Jatropha gossypifolia and Jatropha curcas leaves. Wourld Journal of Pharmaceutical Research 2017; 7(4): 78-90.

Ibrahim NS, Idris UK. Determination of polyphenolic contents and antioxidant potential of leaf extracts from Jatropha curcas (linn). Bayero Journal of Pure And Applied Sciences.2017; 10 (1): 647-649.

Patil R, Patil R, Ahirwar B, Ahirwar D. Antidiabetic activity of leaves of jatropha curcus l.(euphorbiaceae) in alloxan induced diabetes rats. Pharmacology online. 2010; 3: 662-8.

Aina VO, Ibrahim MB, Abdulsalam MS, Adejo GO, Solomon M. Antidiabetic activities of the leaf and bark extracts of Jatropha curcas on alloxan-induced diabetic albino rats. Journal of Natural Sciences Research. 2016; 6(4): 91-95.

Patil RN, Patil RY, Ahirwar B, Ahirwar D. Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats. Asian Pacific Journal of Tropical Medicine. 2011; 4(1): 20-3.

Asuk AA, Dasofunjo K, Okafor AI, Mbina FA. Antidiabetic and antioxidative effects of Jatropha curcas extracts in streptozotocin-induced diabetic rats. British Journal of Medicine and Medical Research. 2015; 5(3); 341.

Johnson M, Olufunmilayo LA, Adegboyega CC, Adetayo OM. Evaluation of antidiabetic and the effect of methanolic leaf extract of Jatropha curcas on some biochemical parameters in alloxan-induced diabetic male albino rats. European Journal of Medicinal Plants. 2014; 4(12): 1501.

Kumar IP, Malhotra I, Sundaresan S, Dev A. Antihyperglycemic and antihyperlipidemic activity of Jatropha gossypifolia methanolic extract in streptozotocin-nicotinamide induced diabetic rats. Asian J Pharm Clin Res. 2017; 10(11): 326-330.

Kumar J, Singh SP, Choudhary GK. Pharmacological evaluation of leaves of Jatropha curcas l. for anti-diabetic activity in alloxan induced diabetic rats. Indian Journal of Animal Sciences. 2016; 86 (4): 387-391.

DOI: https://doi.org/10.26891/JIK.v16i2.2022.115-122

Refbacks

  • There are currently no refbacks.