Korelasi Vitamin D terhadap Kadar Antimullerian Hormone pada Pasien Sindroma Ovarium Polikistik dengan Obesitas di Kota Palembang

Fatimah Usman, Hadrians Kesuma Putra, A Abadi, Salmon Charles Siahaan

Abstract

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine system disorders affecting women of reproductive age. One of the biomarkers for the diagnosis of PCOS is Anti Mullerian Hormone (AMH). Meanwhile, women with PCOS are at higher risk for vitamin D deficiency. The research aims to examine vitamin D and AMH for PCOS women with obesity. PCOS or also known as hyperandrogenic anovulation (HA), or Stein-Leventhal syndrome, is one of the most common endocrine system disorders affecting women of reproductive age. This study was analytic with a cross-sectional approach. The subjects were women with PCOS who went to Dr. M. Hoesin Sriwijaya University (n=30). Inclusion criteria were patients diagnosed with PCOS using Rotterdam, patients who had not received therapy for insulin resistance, and were obese. The exclusion criteria were that the patient couldn’t fulfill Rotterdam criteria and/or option not to participate in this study. The results were that most patients experienced oligomenorrhea (76.7%), the age mean was 31.17 years, and the BMI mean was 33.4 kg/m2. The Spearman correlation test showed a negative correlation between AMH and Vitamin D (p=0.011, correlation coefficient=-0.458). There was no correlation between BMI and vitamin D in PCOS patients, but there was a negative correlation between AMH and vitamin D levels.

Keywords

PCOS, Obesity, Vitamin D, Anti Mullerian Hormone

References

El Hayek S, Bitar L, Hamdar LH, Mirza FG, Daoud G. Poly cystic ovarian syndrome: An updated overview. Frontiers in Physiology. 2016 Apr 5;7.

Kamangar F, Okhovat J-P, Schmidt T, Beshay A, Pasch L, Cedars MI, et al. Polycystic ovary syndrome: Special diagnostic and therapeutic considerations for children. Pediatric Dermatology. 2015 Sep;32(5):571–8.

Bhide P, Homburg R. Anti-Müllerian hormone and polycystic ovary syndrome. Best Practice & Research Clinical Obstetrics & Gynaecology. 2016 Nov;37:38–45.

Krul-Poel YHM, Koenders PP, Steegers-Theunissen RP, ten Boekel E, ter Wee MM, Louwers Y. Vitamin D and metabolic disturbances in polycystic ovary syndrome (SOPK): A cross-sectional study. Plos One. 2018;13(12).

He Y, Zheng D, Shang W, Wang X, Zhao S, Wei Z, et al. Prevalence of oligomenorrhea among women of childbearing age in China: A large community-based study. Women’s Health. 2020 Jan 7;16:174550652092861.

Harris HR, Babic A, Webb PM, Nagle CM, Jordan SJ, Risch HA, et al. Polycystic ovary syndrome, oligomenorrhea, and risk of ovarian cancer histotypes: Evidence from the ovarian cancer association consortium. Cancer Epidemiology Biomarkers & Prevention. 2018 Feb;27(2):174–82.

Siahaan SC, Henderi H, V AC, P AK. Analysis regarding quality of life of menopausal women on clinical disorders during menopausal period, in suko manunggal sub-district Surabaya in 2019. Berkala Kedokteran.2019; 15.

Park Y-J, Shin H, Jeon S, Cho I, Kim Y-J. Menstrual cycle patterns and the prevalence of premenstrual syndrome and polycystic ovary syndrome in Korean young adult women. Healthcare. 2021 Jan 7;9(1):56.

Panidis D, Tziomalos K, Papadakis E, Chatzis P, Kandaraki E, Tsourdi E, et al. Associations of menstrual cycle irregularities with age, obesity and phenotype in patients with polycystic ovary syndrome. HORMONES. 2015 Jun 30;

Rojas J, Chávez M, Olivar L, Rojas M, Morillo J, Mejías J, et al. Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth. International Journal of Reproductive Medicine. 2014;2014:1–17.

Damayanti AY, Indarto D, Wasita B, Ardyanto TD. Indeks massa tubuh, asupan vitamin D, dan serum 25-hydroxyvitamin D pada pasien kanker payudara Related papers. Jurnal Gizi Klinik Indonesia [Internet]. 2017;14(2):56–63. Available from: https://jurnal.ugm.ac.id/jgki

Bindayel IA. Effect of age and body mass index on vitamin D level in children with asthma in Riyadh. Scientific Reports. 2021 Dec 1;11(1):11522.

Bakeer E, Radwan R, el Mandoury A, el Rahman AA, Gad M, el Maksoud SA. Anti-müllerian hormone as a diagnostic marker in Egyptian infertile polycystic ovary syndrome females: correlations with vitamin D, total testosterone, dyslipidemia and anthropometric parameters. Journal of Medical Biochemistry. 2018 Dec 1;37(4):448–55.

Siahaan SC, Santoso B, Widjiati. Effectiveness of Moringa oleifera leaves on TNF-α expression, insulin levels, glucose levels and follicle count in Rattus norvegicus PCOS model. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2022 Oct 26; 3255-3270.

Siahaan SC, Henderi H, Sudibjo, Safitri NPD, Wakas BE, Pratama MFI. Intervensi ibu hamil dengan kurang energi kalori melalui suplementasi mikronutrien di Surabaya tahun 2019. Majalah Kedokteran Andalas. 2021 Mei; 44 (1):17-27.

Refbacks

  • There are currently no refbacks.