Pengaruh Pemberian Antioksidan Vitamin C Dan E Terhadap Konsentrasi Spermatozoa Mencit (Mus Musculus) Yang Dipapar Asap Rokok

Ervina Wati Harahap, Normalina Sandora, Winarto Winarto


Free radical that are released in cigarette smoke, believed to play an important role in male infertility. The free radical
produces Reactive Oxygen Species (ROS) that is found increased in male smokers. ROS is one of the free radicals
component can be neutralized by vitamin C and E as an antioxidant. This study using those agents to the fifteen minutes
half piece cigarette to expose mice and count their sperm as the fertilility parameter. The research design used was post
test-only control group with twenty mice were divided into five groups. A group of no smoke exposed was categorized
as a baseline control, the exposed groups were consisted of one group without antioxidant, one group with vitamin C
treatment, a group of vitamin E treatment and at last the combination of vitamin C and E. All groups were treated
for fourteen days. The results were analyzed using oneway ANOVA with p<0.05. It is obviously proven that the
combination of vitamin C and vitamin E treatment on the usual dose gave the highest sperm count compared to other


Vitamin C, vitamin E, cigarette smoke, consentration of sperm

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