Pola Sensitivitas Isolat Klinis Bakteri Gram Negatif Multiresisten Obat Terhadap Fosfomisin dari Beberapa Rumah Sakit Kota Pekanbaru

Dewi Anggraini, Atya Nasmah, Fauzia Andrini

Abstract

Over the last few years, there has been a decrease in amount of effective antibiotics, coincide with the lack of new
antibiotics relevant for the treatment of Gram negative multi-drug resistant organisms infections. This problem can be
overcome by the assessment and re-introduction of old antibiotics such as fosfomycin. Fosfomycin is a broad spectrum
antibiotic that is bactericidal. This study aimed to find out the sensitivity pattern of clinical isolate multi-drug resistant
Gram negative bacteria to fosfomycin with descriptive cross sectional method. The sample used in this study was
clinical isolates collection of Microbiology Laboratory Faculty of Medicine, University of Riau from Hospitals in
Pekanbaru. The result showedsensitivity to fosfomycin Escherichia coli producing ESBL (88%), Klebsiella pneumoniae
producing ESBL (95%), Acinotobacter baumannii resistant meropenem (27%), Pseudomonas aeruginosa resistant
meropenem (36%) and K.pneumoniae resistant meropenem (70%). Fosfomycin can be used as alternative therapy for
infections caused by Gram-negative Multi-drug resistant organisms.

Keywords

fosfomycin, Gram-negative, multi-drug resistant organisms, pekanbaru

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