Pengaruh Pemberian Asam Alfa Lipoat terhadap Kadar Kolesterol Total pada Tikus Diabetes Melitus Tipe 2

Abstract

Hypercholesterolemia is complication in type 2 diabetes. Alpha lipoic acid (ALA) reduced total cholesterol by modulating
cholesterol synthesis pathway and reduced cholesterol biosynthesis genes expression. The goal of this research was
to investigate the prohibition of hypercholesterolemia in type 2 diabetes rat by ALA. Fifteen adult male wistar rats (2-
3 months, 200-250 g body weight) were segregated into three groups (standard, type 2 diabetes and type 2 diabetes +
ALA). Type 2 diabetes induced by streptozotocin 65 mg/kg and nicotinamide 110 mg/kg. ALA was given for 3 weeks
after type 2 diabetes induced.After 31 days total cholesterol of groups labelled is measured. The result showed there
was significant difference between ALA and type 2 diabetes groups (p= 0.012), and there was no significant difference
between ALA and standard groups (p= 0.591). As the conclusion, this study proves that ALA has effects on total
cholesterol in type 2 diabetes rats.